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COVID-19 is a widespread contagious viral infection that can severely affect the respiratory system. Although many people recover from using the disease without special care or treatment, pregnant women are particularly vulnerable to pulmonary infections due to their hangers systems system and physiology. To investigate the treatment provided to pregnant women who are PCR-positive for COVID-19 in their early three months of pregnancy, a reanalyzed analyzed data from 84 participants who received treatment at Tangerang Regional Hospital in 2 study was the study conducted based on an ases of observational investigation with a cross-sectional approach. It assembled the data for analysis of the chi-square test. The results showed that 92.9% of participants underwent a cesarean section, while the remaining 7.1% were discharged after giving birth typically or recovering. Additionally, the study did not find any correlation between factors such as age, education, work, gravida, ANC visit, and the impact of COVID-19 on the third trimester of pregnancy at Tangerang Hospital in 2022. The study recommends that pregnant women seek information about pregnancy care from healthcare providers, particularly midwives, posyandu officers, and the media, to make well-known decisions about their health and well-being during this critical period, ensuring a safe and healthy pregnancy outcome.
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A pandemic is a complex phenomenon that requires multi-directional corrective actions and, above all, preventive measures. Managing crises such as the COVID-19 pandemic has proven to be the biggest challenge facing healthcare organizations. In the process of ensuring a safe hospital environment for patients and staff, various models and adequate approaches to crisis management were applied. In order to explore the opinion of health care managers on the challenges and practices of providing a safe hospital environment in the management of the COVID-19 pandemic, a qualitative survey - a semi-structured interview - was conducted among 35 health care managers. Based on the results of the interviews with head and senior nurses, the main themes related to "challenges" and "practices" during the pandemic related to the practice of health care professionals were identified. Challenges include: developing and implementing measures to manage safe hospital environment during the COVID-19 pandemic;staff shortages and psychological problems. Practices include changes in nurses' work schedules, nurse rotation, staff training, organizational support. Healthcare managers have provided new and safe practices for managing staff and the environment during the COVID-19 pandemic. The results of this study show that healthcare managers perceive management during the COVID-19 pandemic differently than other crises. In their opinion, managing in these difficult conditions is very complex and requires greater flexibility on the part of managers in accordance with constantly changing circumstances.
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Background: Studies show that wearing personal protective equipment (PPE) for long periods of time can lead to discomfort such as headaches, which could affect the performance of healthcare workers. The aim of this study was to determine the prevalence and risk factors of headaches related to PPE in healthcare workers at a COVID-19 referral hospital. Methods: A cross-sectional study was conducted involving 174 healthcare workers in a COVID-19 referral hospital in Bali. We conducted interviews using a questionnaire that consisted of three main parts: characteristics of the subjects, PPE usage, and PPE-associated headaches. A multiple logistic regression was used to analyze the data. Results: The analysis results showed that the PPE-associated headaches had a prevalence of 63.8% and were gradual in onset, pressure-like in quality (46%), and mild in intensity (80.1%). PPE level III-associated headache was the most common type. The majority of the participants had headaches up to 6 hours after using the protective gear, but improving within 15-30 minutes of removal and/or after pharmacotherapy. A Chi-squared analysis showed a statistically significant association between duration of PPE use, working units, and PPE levels (p<0.05). A logistic regression analysis found a significant relationship between PPE level and headache occurrence (OR=4.826;95%CI: 2.433-9.572;p<0.001). Conclusion: The frequency of PPE-associated headache was high and the PPE level was a risk factor of headache among healthcare workers. Better strategies are needed to reduce the duration of PPE exposure so that the work performance and quality of life of healthcare workers are not significantly affected.
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Background: Healthcare workers (HCWs) in India are facing physical and psychological pressure. The pandemic has significant psychological impacts. Hence, we wanted to assess the mental stress and social stress among HCWs during the second wave of COVID-19. Aim and Objectives: Assessment of the mental distress among HCWs of tertiary care level institution during second wave of COVID-19 with the following objectives: (1) To know the sociodemographic characteristics of the HCWs of tertiary care center and (2) to assess the psychological stress among healthcare workers of a tertiary health center. Material(s) and Method(s): It is a cross-sectional and observational study conducted in hospital setting, in a tertiary care setting. Data were collected from 196 HCWs of the institute. Institutional ethical clearance was taken before the study. Structured questionnaire included sociodemographic variables, work-related variables, and variables to assess social stress. We used hospital anxiety and depression scoring questionnaire to assess anxiety and depression. Data were collected through personal interviews and online through Google forms after taking informed consent. Descriptive statistics and Chi-square tests are used analyzed using Statistical Package for the Social Sciences Version 21 for Statistical analysis. Result(s): A total of 196 HCWs, 121 doctors, 74 nursing staff, and one ward staff participated in the study. Nursing staff were at higher risk for anxiety and depression, that is, 29% and 25% than others. Females were slightly more anxious (29%) and depressed (17%) than males. HCWs who are Muslim by religion were at more mental distress. Media exposure of more than 3 h had increased risk of mental distress. HCWs with other frontline COVID warrior as a partner were both anxious (40%) and depressed (20%). Anxiety (35%) was more among those who's family members got COVID positive. About 25% of them faced social stigma, 55% of them faced issue of isolation with in the community, and 14% of them faced acts of violence which is unacceptable. Conclusion(s): Although its second wave HCWs are still having psychological distress which needs to be addressed. Social stress that they are facing is significant and is associated with higher anxiety and depression, which has to be taken seriously.Copyright © 2023, Mr Bhawani Singh. All rights reserved.
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Introduction : Understanding the epidemiological and clinical profile of COVID-19 cases and pattern of disease is very much required for future preparedness. Objective : To assess the epidemiological and clinical profile of cases of COVID 19 Method : Cross sectional descriptive study was carried out at a Rural Health Training Centre (RHTC). All cases reported in the month of January 2022were included in the study. The information about the epidemiological and clinical profile was collected from RHTC records by conducting telephonic interview. Results : Total 83 cases were reported. Among them, 43 (54.4%) cases were in age group 20-39 years. Male: Female ratiowas 1.37:1. Therewas one death and patient had ovarian cancer as co-morbidity. Total 71 patients could be contacted for telephonic interview. Fever was most common symptom andwas presenting symptom on first day followed by cough/cold and sore throat. None had shortness of breath or chest pain. Hospitalization rate was 5.63% and none required oxygen supplementation or intensive care. Recovery period was 3-5 days. Out of total, 90% cases were fully vaccinated and 95.8% had knowledge of CAB. Diabetes and hypertension were most common comorbidities andwere statistically significantlymore in age > 40 years. Conclusions : The COVID-19 cases in the beginning of year 2022 had clinical presentation different than the earlier waves. Periodic situational analysis can guide in policymaking for handling this pandemic in future.
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Coronavirus disease 2019 (COVID-19) has been admitted by WHO as a global pandemic. The successes-ness in controlling COVID-19 is extremely affected by the knowledge and perception of society. Apothecary students must be competent in carrying out the health promotion effort;one of them is through education. Discovering the impact of education from apothecary students in improving knowledge and perception of the society in controlling COVID-19. One group Quasi-experimental design without a control group (n=102). The data was conducted in March-April 2020 using a validated questionnaire containing the respondents' demographic, knowledge, and perception of COVID-19. This research is 18 years old, does not work as a health worker/medical personnel, domiciled in Yogyakarta, and fills up the pre-test and post-test questionnaire. The data were analyzed descriptively and used the Wilcoxon test (p<0.05) as the statistic test. Most respondents are 52.9% women, 34.31% aged 36-45, with 52.94% having a high school education level. The survey result shows that 71.57% of respondents admit that they know about COVID-19 from television and 2.43% from social media. The answer distribution of questioner on knowledge and perception shows improvements in the pre-test and post-test scores. The Wilcoxon test result, the influence of education on respondents' knowledge and perception, shows the significance of p value=0.000 with the outcome of pre-test and post-test scores with the good category are 67.65% and 5.29%. The presentation of education from apothecary students significantly influences society's knowledge and perception of controlling COVID-19.
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Background: Phase III trials, corroborated by early post-marketing data globally show that COVID-19 vaccination reduces the risk of severe disease, hospitalisation and death. Despite this, vaccine hesitancy persists amongst some healthcare workers. This study aimed to assess the acceptability of the COVID-19 vaccine amongst South African pharmacists and highlight vaccine-related concerns and predictors of vaccination hesitancy.Methods: Nested within an online survey (14 April 2021 to 18 May 2021) assessing the mental health of South African pharmacists during the COVID-19 pandemic, vaccine acceptability and vaccine-related concerns were studied. A multivariate logistic regression analysis identified factors associated with vaccine hesitancy.Results: From 2 454 registered South African pharmacists sampled, 755 responded to the vaccine acceptability survey (response rate: 30.8%). Vaccine acceptability was 71.9%, while 72.4% and 53.3% were concerned about serious COVID-19 vaccine-related side effects and the lack of vaccine safety data, respectively. Pharmacists aged 20-30 years were more likely to be vaccine-hesitant compared to those aged > 60 years (aOR 3.2, 95% CI 1.1-9.6). Compared to their Caucasian colleagues, Black/African pharmacists were twice as likely to be vaccine-hesitant (aOR2.2, 95% CI 1.2-4.0).Conclusion: COVID-19 vaccine hesitancy among South African pharmacists exists amongst a small but significant proportion. Targeted interventions to address concerns are necessary.
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IMMUNION (Improving IMMunisation cooperation in the European UNION) is a European project having the objective to support vaccine strategies. The project (active from April 2021 to March 2023) has contributed to improve knowledge on vaccines and vaccinations among health professionals and the information circulation in different target groups, through a multistakeholder collaboration including institutions, associations and media. The IMMUNION consortium has been focusing on activities of survey, professional training and communication, even with the aim to sustain visibility and role of the Coalition for Vaccination. In particular, ISS has coordinated the Work Package on finalising vaccine communication tools to increase vaccination compliance in target communities.
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Health is a multifaceted issue and providing and promoting all its dimensions is an interdisciplinary task. Examination of crisis conditions shows that the retention of health human resources is very important due to the high volume of work in these conditions. Due to the severity of the prevalence of COVID-19, the health system must have an acceptable plan for dealing with this disease. Therefore, the purpose of this study is to investigate the factors affecting the retention and stability of human resources in crises. We used a critical review method using specific keywords ("human resources retention", "COVID-19", and some other related keywords) in, Pubmed, Scopus, Google Scholar, and SID databases until September 2022 without time limitation. Reviewers screened founded studies separately and finally, we summarized the main results of 12 eligible articles. Four main strategies (Organizational management and leadership, risk reduction, improving the mental health of health workers, and financial and welfare support) are possible solutions to reduce healthcare workers' burnout and increase their resilience to this hard situation. It seems that planning, appropriate policy-making to implement the solutions found, division of tasks, and compilation of a national document on human resource protection in crises with the cooperation of people and officials can be very helpful.
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Health-care providers or health-care workers (HCWs) are at higher risk of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection when compared to the general population. An early routine screening of both symptomatic and asymptomatic HCWs is essential to prevent transmission of infection and thus the nosocomial spread. The cumulative prevalence of SARS-CoV-2 infection among Indian HCWs is unknown. This systematic review was aimed to analyse the prevalence of SARS-Co-V2 disease (COVID-19) among Indian HCWs. Data were collected from a comprehensive computerised search in PubMed, Google Scholar, ScienceDirect, ResearchGate, Scopus and Web of Science using the terms 'Prevalence of COVID-19 among HCWs in India' and 'prevalence of SARS-CoV-2 among HCWs in India'. Results of original research papers and meta-analysis published were collected and data analysed. Results of seven studies on 31656 HCWs in India were pooled. Overall, average prevalence of COVID-19 among the HCWs was 12.3%. Majorities were frontline workers irrespective of the gender. Most of the cases were symptomatic, with cough and fever as major clinical presentations. Findings suggest that adequate organisation of clinical wards and personnel, appropriate personal protective equipment supply and training of all workers directly and repeatedly exposed to COVID-19 patients should be prioritised to decrease the risk of infection. Furthermore, the duty time of HCWs who works in COVID treating area should be minimised.
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BACKGROUND: Lactobacillus coryniformis K8 CECT5711 has immune-modulating properties, enhances the immune response to viral antigens leading to the production of specific antibodies, and has anti-inflammatory activity, which may help to prevent uncontrolled inflammatory processes leading to respiratory and other organ failures. OBJECTIVE: The purpose of this study is to evaluate the effect of the consumption of a probiotic strain on the incidence and severity of COVID-19 in health personnel who carry out their professional work among patients with infection or suspected infection by SARS-CoV-2. METHODS: This is a double-blind randomized clinical trial in which the experimental group will receive a capsule of L coryniformis K8 per day (3×109 colony former units/day), and the control group will receive a daily placebo capsule consisting of maltodextrin. A sample size of 314 volunteers was calculated. Volunteers must meet the following inclusion criteria: older than 20 years and active health personnel caring for patients with COVID-19, including all professionals such as medical doctors, nurses, and caretakers at the 2 referral hospitals that treat patients with COVID-19. The main outcome of the clinical trial will be the incidence of symptomatic infection by SARS-CoV-2 in personnel who care for patients with suspected or confirmed COVID-19. RESULTS: The study had to be extended to the 2 referral hospitals that treat patients with COVID-19 in the province of Granada (Andalusia, Spain); Hospital San Cecilio and Hospital Virgen de las Nieves. A total of 255 individuals met the inclusion criteria and were randomly assigned to one of the 2 groups. CONCLUSIONS: The results of this randomized controlled trial will provide valuable information regarding the administration of L coryniformis K8 against COVID-19, including whether there are fewer infectious processes due to this virus or, in case of occurrence, whether the disease is milder in participants taking the probiotic strain. TRIAL REGISTRATION: ClinicalTrials.gov NCT04366180; http://www.clinicaltrials.gov/ct2/show/NCT04366180. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR1-10.2196/37857.
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BACKGROUND: Burnout syndrome (BS) has a negative impact among health professionals. AIMS: Our research objective is to quantify the level of burnout in health workers of the Spanish National Health System during the COVID-19 pandemic using and comparing two independent measurement instruments. METHODS: Cross-sectional, descriptive and multicenter study conducted through an anonymous online survey among health workers of the National Health System, measuring the level of burnout using the Maslach Burnout Inventory (MBI) and the Copenhagen Burnout Inventory (CBI). RESULTS: A total of 448 questionnaires were analyzed, the mean age of the participants was 43.53 years (range: 20-64), 365 (81.5%) women. 161 (35.9%) participants presented BS measured with the MBI and 304 (67.9%) measured with the CBI. Regarding work contract, those who had greater job stability presented a higher degree of cynicism with respect to the eventual ones (p = .010), the eventual ones presenting higher mean scores in professional efficacy (p = .034). Urban workers had higher scores of exhaustion (p < .001) and cynicism (p < .001) than those living in rural areas. When comparing both tests, a high predictive value for exhaustion and cynicism was found to measure BS through the CBI (AUC = 0.92 and 0.84, respectively) and a low AUC with respect to the predictive value for efficacy (AUC = 0, 59). CONCLUSIONS: The results obtained show a high level of BS among the health workers who participated in our study. Both tests have an excellent correlation in the degree of exhaustion and cynicism, but not in efficacy. The BS measurement must be performed with at least two validated instruments to increase its reliability.
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Introduction: SARS-CoV-2 has created a significant challenge to healthcare systems, since the disease has spread rapidly, outweighing hospital capacity and exposing Health Care Workers (HCWs) to the risk of infection. The main objective of this study shows the HCW's self-reported use of Personal Protective Equipment (PPE), symptoms, and exposure to revealed and suspected people during the pandemic, as well as the implementation of infection prevention and control (IPC) guidelines that effectively limit the spread of the infection among healthcare personnel. Method: A single-center retrospective cohort study has been done at a tertiary care hospital. There were 3,651 hospital employees of these 1,890 HCWs and 1,761 nonclinical staff among those who were proven or suspected COVID-19 cases and had symptoms were included. The data was gathered using a standardized self-assessment questionnaire. Information about quarantine protocol and line listing was collected through telephonic conversations. Result: The majority of the participants were males (66%). The average age was 32.1±7.62. Out of 432 HCWs, 32.9% with positive SARS-CoV-2 PCR findings were nurses, 19.2% were doctors, and 47.9% were non-clinical employees from the hospital's inpatient and outpatient departments. 31.5% had a higher-risk exposure, 64.1% had a moderate-risk exposure, and 4.4% of practitioners with COVID-19 had a lower-risk exposure. A statistically significant association was found between COVID-19 disease and adherence to PPE and risk exposure. Conclusion: This study represents the healthcare workers' experience with COVID-19 patients in the early stages of the pandemic and emphasizes the measures required to overcome the problems, however, this study highlights that HCWs are being progressively infected with COVID-19 as a result of inadequate/ inappropriate PPE wear.
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BACKGROUND: The COVID-19 pandemic has led to a flood of-often contradictory-evidence. HCWs had to develop strategies to locate information that supported their work. We investigated the information-seeking of different HCW groups in Germany. METHODS: In December 2020, we conducted online surveys on COVID-19 information sources, strategies, assigned trustworthiness, and barriers-and in February 2021, on COVID-19 vaccination information sources. Results were analyzed descriptively; group comparisons were performed using χ2-tests. RESULTS: For general COVID-19-related medical information (413 participants), non-physicians most often selected official websites (57%), TV (57%), and e-mail/newsletters (46%) as preferred information sources-physicians chose official websites (63%), e-mail/newsletters (56%), and professional journals (55%). Non-physician HCWs used Facebook/YouTube more frequently. The main barriers were insufficient time and access issues. Non-physicians chose abstracts (66%), videos (45%), and webinars (40%) as preferred information strategy; physicians: overviews with algorithms (66%), abstracts (62%), webinars (48%). Information seeking on COVID-19 vaccination (2700 participants) was quite similar, however, with newspapers being more often used by non-physicians (63%) vs. physician HCWs (70%). CONCLUSION: Non-physician HCWs more often consulted public information sources. Employers/institutions should ensure the supply of professional, targeted COVID-19 information for different HCW groups.
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Background: Gender discrimination among healthcare workers (HCWs) negatively impacts their mental health and career development; however, few studies have explored how experiences of gender discrimination change during times of health system strain. Methods: This survey-based study assesses the associations between gender discrimination and four stress-related mental health outcomes (posttraumatic stress, depression, anxiety, and burnout), as well as the qualitative experiences of gender discrimination in healthcare during the COVID-19 pandemic. Results: Among women, increased gender discrimination was associated with heightened symptoms of posttraumatic stress, depression, anxiety, and burnout after adjusting for demographics and pandemic-related stressors; however, among men, increased gender discrimination was only associated with heightened symptoms of depression. Using thematic analysis, we identified five themes that describe experiences of gender discrimination faced by women in healthcare, including differential valuing of work and contributions, gendered roles and assumptions about roles, maternal discrimination, objectification, and "old boys club." We also identified two themes describing how men perceived gender discrimination, including instances of symbolic discrimination and woman provider preference. Conclusion: These findings suggest that experiences of gender discrimination persist during times of health system strain and negatively impact women HCWs' mental health.
Subject(s)
COVID-19 , Mental Health , Male , Humans , Female , Sexism , Pandemics , COVID-19/epidemiology , Anxiety , Health Personnel , DepressionABSTRACT
The health and wellbeing of nurses and midwives are essential to the quality of care they can provide for people and communities, affecting their compassion, professionalism and effectiveness. Ensuring that working conditions across all settings-in primary, secondary, mental health, community and social careare supporting nurses and midwives in their work, is fundamental to ensuring the best outcomes for people who need health and care services. The coronavirus pandemic (Covid-19) has emerged as a serious health crisis of global proportion. This disease has created health emergencies, which had taken a toll on the wellbeing of many health workers. Particularly, the nursing and midwifery professions have faced numerous challenges causing ethical dilemmas in their practices and exacerbating their psychosocial wellness. In this commentary, we explore the impact of Covid-19 on the nursing and midwifery practices in South Africa.
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Background: Nurses serve at the frontline during disease outbreaks. While measures have been adopted to control the rapid spread of the Covid-19 pandemic, little is known about the level of compliance of nurses to standard precaution practices during the early phase of the pandemic. Objective: This study aimed to assess compliance with standard precaution practices (SPPs) among 713 nurses in Nigerian hospitals during the early phase of the pandemic. Method: The study adopted a descriptive cross-sectional design using an anonymous online questionnaire to elicit data from respondents. Data were analysed with the Statistical Package for the Social Sciences, version 25. Chisquare test and multiple regression analyses were also conducted where appropriate. Results: Findings from this study indicated that 448 (62.8%) of the respondents had good knowledge of Covid-19 and 265 (37.2%) had poor knowledge. Also, 529 (74.2%) had good compliance with the practice of standard precautions, and 184 (25.8%) showed non-compliance. A significant association was found between the age of nurses (X-2=14.034 p=0.015), years of experience (X-2=8. 636 p =0.035) and their overall compliance with the practice of standard precautions. Conclusion: During the early phase of the Covid-19 pandemic in Nigeria, although over an average of the nurses had good knowledge of the disease, over one-third had poor knowledge, and one-quarter showed poor compliance with standard precautions. Interventions to improve the knowledge and compliance of health workers during the early phase of disease outbreaks are hereby advocated, as 21.3% had no previous training on Covid-19.
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Emerging infectious diseases (EIDs) and their determinants are attracting increasing attention from scientists, with approximately 75% of EIDs being zoonotic. Among these pathogens are viruses belonging to the Coronaviridae family. Until 2002, CoVs were primarily studied for scientific or veterinary purposes. However, the world's view on the virulence of CoVs changed in 2002 when a zoonotic betacoronavirus named SARS-CoV appeared in southern China and caused a global epidemic with over 8,000 cases. Ten years later, in the Middle East, another zoonotic betacoronavirus, MERS-CoV, emerged and caused 2,521 cases. A new highly contagious CoV named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in 2019, causing the largest pandemic of the modern era known as coronavirus disease 2019 (COVID-19). Vaccination is one of the most effective methods to reduce the risk of severe illness, hospitalization, and death. The main objective of the study was to evaluate the acceptability of the COVID-19 vaccine among healthcare workers, describe the main adverse reactions, and identify the need for medication administration based on the severity of the adverse reactions manifested.Copyright © 2023, Romanian Society for Pharmaceutical Sciences. All rights reserved.
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Background: Covid-19 has been declared a global pandemic by WHO. Health Care Workers (HCWs) being the front-line warriors have been most exposed to the SARS-CoV-2 virus. Vaccine hesitancy against Covid-19 has been seen among HCWs. The main aim of the research was to find the hesitancy rates of vaccine among HCWs and the pulling and pushing factors to get vaccinated. Methods: A descriptive cross-sectional study was conducted on HCWs. Questionnaires on Google forms were sent to all participants through their WhatsApp number and data was analysed through SPSS version 23.0. Results: Out of 81 HCWs selected, 51.9% (n=42) were initially hesitant when the vaccine was first introduced. The main pulling factor initially to get vaccinated was to shield loved ones, 38.75% (n=31) and 46.2% (n=37) of them received a booster dose of vaccine mainly due to employment requirements. Out of the total, 19.75% (n=16) are still hesitant even after vaccination and the most common pushing factors were fear of the side effects and inadequately tested vaccines. Conclusion: Though the majority of the HCWs got vaccinated, vaccine hesitancy is still present among the HCWs and the major reason is uncertainty about the side effects it could cause in the long term.
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BACKGROUND: Efficacy of COVID vaccines has been evaluated in various studies. The interim analysis from four randomized controlled trials in UK, Brazil, and south Africa regarding efficacy of two doses of the vaccine was found to be 70.4% (95.8% CI 54.8-80.6). There is a limited data on follow-up Ab titer post vaccination. Hence, the current study is first of its kind with the objective to determine vaccine long term efficacy and its determinants. METHODS: Health Care Workers (HCW) from Apollo Multispeciality Hospitals, Kolkata who underwent Covishield vaccination from January 2021 to April 2021 were included in the study. Serological testing was done prior to first and second dose of vaccinations, and additionally around six months post second dose. RESULTS: Between January 2021 to April 2021, 2032 HCW, with predominant age of less than 30 years (44.83%) and male gender (61.96%) undergoing Covishield vaccination were enrolled. Antibodies were detected in 953 (46.9%) individuals prior to first dose, 1449 out of 1495 (96.9%) remained positive prior to second dose and 465 out of 504 (92.3%) HCW after 6 months and remaining 39 (7.7%) either had lost or never had antibodies in their blood. The mean +or- SD value of first, second and third antibodies were 2.35 +or- 3.10, 10.46 +or- 4.84 and 8.75 +or- 4.88 respectively. CONCLUSIONS: This study provides long observation period, covering the complete progress of the pandemic which provides a "real-life" picture of the antibody level dynamics over time, and after vaccination.